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Development of a novel drug discovery platform for human skeletal muscle wasting

Marwah Abd Al Samid

2017

Background: Muscle wasting in ageing (sarcopenia) is a significant public health concern, culminating in weakness, frailty and loss of independence. Despite several decades of research using model organisms, animals and two dimensional (2D) muscle cell cultures, there remains no cure or treatment for muscle wasting. Animal models and cells do not represent human muscle ageing and disease, while 2D models do not recapitulate the 3D structure of muscle tissue and lack the m...

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