Hyperglycaemia and tubulointerstitial fibrosis in renal proximal tubular epithelial cells.
F Alsehli, N Ahmed and L Shalamanova
Centre for Biomedicine, School of Healthcare Science, Manchester Metropolitan University, Manchester, UK
Background: Renal tubulointerstitial fibrosis (TIF) is the hallmark of chronic and end-stage renal disease. Around 40% of the diabetic patients develop diabetic nephropathy which is characterised by abnormal accumulation of extrac...
Over the past few decades technology in the millimetre wave band has shown a steady and consistent development and increased usage, with a wide variety of devices and system architectures (imaging, non-imaging, radiometers and radars) sensors becoming available. As an imaging sensor, these systems can deliver spatial resolutions of less than the wavelength, which in the millimetre wave band is down to about 1.0 mm. This property enables highly localised measurements to be made of skin which cann...
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of rare bone marrow disorders
which lead to the increased proliferation of haematopoietic stem cells and subsequent increased
myeloid cell count. Classic MPNs include the Philadelphia chromosome-positive disease, chronic
myeloid leukaemia (CML), while polycythaemia vera (PV), essential thrombocythemia (ET) and
myelofibrosis (MF) belong to the Philadelphia-chromosome negative diseases. Dysregulation of the
Social stressors such as impaired maternal care and family conflict are robust challenges, which can have long-term physiological and behavioural effects on the offspring.
The aim of this study is to explore mechanisms underlying the inheritance of stress including: 1, epigenetic, neuroendocrine and immune alterations; 2, factors in breast milk; 3, genetic susceptibilities.
A rat model of transgenerational maternal chronic social stress (CSS) has been studied for ...